Long non‑coding RNAs: Key regulators involved in metabolic reprogramming in cancer (Review).

Abstract

Metabolism is defined as the biochemical processes that produce or consume energy in living organisms. Otto Warburg suggested that cancer is a metabolic disease, thus metabolic reprogramming is widely considered as an emerging hallmark of cancer cells. Long non‑coding RNAs (lncRNAs), which are defined as transcripts >200 nucleotides with limited protein coding potential, are involved in cancer metabolism. lncRNAs can control pathophysiological processes of cancer by regulating gene expression at epigenetic, transcriptional and post‑transcriptional levels. The process of tumorigenesis is usually accompanied by alterations in metabolic patterns, involving glycolysis, the tricarboxylic acid cycle, mitochondrial oxidative phosphorylation, the pentose phosphate signaling pathway, glutamine metabolism and lipid metabolism, which is also known as metabolic reprogramming. The present review summarized the functions of lncRNAs in cancer metabolism and discussed how the dysregulation of lncRNAs contributed to metabolic reprogramming and tumorigenesis, which may provide novel therapeutic targets for cancer.

• Authors: Chunxia Liu, Hao Li, Fenglan Chu, Xi Zhou, Rui Xie, Qiongqiong Wei, Shiming Yang, Tao Li, Sicheng Liang, Muhan Lü
• Journal: Oncology reports (Oncol Rep) Vol. 45 Issue 5 (05 2021) ISSN: 1791-2431 [Electronic] Greece
• PMID: 33760177 (Publication Type: Journal Article, Review)

Chemical References

• RNA, Long Noncoding

Topics

• Carcinogenesis (genetics, pathology)
• Citric Acid Cycle (genetics)
• Epigenesis, Genetic
• Gene Expression Regulation, Neoplastic
• Humans
• Lipid Metabolism (genetics)
• Neoplasms (genetics, pathology)
• Oxidative Phosphorylation
• Pentose Phosphate Pathway (genetics)
• RNA, Long Noncoding (metabolism)
• Warburg Effect, Oncologic