[Intravenous and oral treatment with amantadine sulfate in Parkinson disease].

The rapid efficacy of amantadine on akinesia and rigidity in Parkinson's disease is generally known. The duration of this therapeutic result is however controversial. Some authors have reported a loss of efficacy after only a few weeks of therapy. The success of a short-term parenteral and subsequently oral long-term treatment with amantadine sulphate in 8 Parkinsonian patients was tested by means of clinical and neuropsychological examinations and by monitoring the serum concentration over the course of half a year. A ten-day intravenous treatment with amantadine sulphate (200 mg daily) led to a significant improvement in the clinical and psychological test results. This attained improvement could be maintained for 6 months with oral therapy consisting of 600 mg amantadine sulphate. There were strong interindividual variations in serum concentration.
AuthorsM Brenner, A Haass, P Jacobi, K Schimrigk
JournalDer Nervenarzt (Nervenarzt) Vol. 59 Issue 3 Pg. 180-4 (Mar 1988) ISSN: 0028-2804 [Print] GERMANY, WEST
Vernacular TitleIntravenöse und orale Behandlung mit Amantadinsulfat bei der Parkinsonkrankheit.
PMID3374720 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Amantadine
  • Administration, Oral
  • Amantadine (administration & dosage, pharmacokinetics)
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Parkinson Disease (blood, drug therapy)

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