HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Testing a short-term feeding trial to assess compositional and histopathological changes in hearts of rats fed vegetable oils.

Abstract
Male, female and castrated rats, three wk of age, were fed a low-fat diet for 14 wk followed by high-fat diets (20% by weight) for one wk containing graded levels of erucic acid from 1 to 50%, to evaluate the effect of short-term feeding and interaction of male sex hormones on formation of heart lesions. Some rats within each group were returned to the low-fat diet for one wk after the test period. For comparison, one group of three-wk-old male rats was fed the high fat 50% erucic acid diet for 15 wk. Erucic acid depressed growth rate and food consumption and increased cardiac lipidosis and triglycerides proportional to the erucic acid content of the diet. There were no sex differences, and the effects disappeared once rats were returned to the low-fat diet for one week. There was a significance (P less than 0.05) in the incidence of myocardial necrosis among male rats fed increased levels of erucic acid for one week, but the response was not linear to the increase in dietary erucic acid. Furthermore, the response was much less than in males fed the 50% erucic acid diet continually for 15 weeks. These results suggest that the short-term model is not a suitable substitute for the long-term feeding trial to test the cardiopathogenicity of a vegetable oil. The significantly lower incidence in myocardial lesions in female and castrated male rats compared with male rats suggests involvement of sex hormones.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsJ K Kramer, E R Farnworth, B K Thompson, A H Corner
JournalLipids (Lipids) Vol. 23 Issue 3 Pg. 199-206 (Mar 1988) ISSN: 0024-4201 [Print] United States
PMID3374273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dietary Fats
  • Erucic Acids
  • Fatty Acids, Monounsaturated
  • Gonadal Steroid Hormones
  • Phospholipids
  • Plant Oils
  • Sphingomyelins
Topics
  • Animals
  • Cardiomyopathies (metabolism, pathology)
  • Castration
  • Dietary Fats (adverse effects)
  • Erucic Acids (adverse effects)
  • Fatty Acids, Monounsaturated (adverse effects)
  • Female
  • Gonadal Steroid Hormones (physiology)
  • Lipidoses (chemically induced, metabolism, pathology)
  • Male
  • Myocardium (analysis, pathology)
  • Necrosis
  • Phospholipids (analysis)
  • Plant Oils (adverse effects)
  • Rats
  • Rats, Inbred Strains
  • Sphingomyelins (analysis)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: