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Acute eosinophilic leukemia with a (10;11) chromosomal translocation.

Abstract
We report a patient with acute eosinophilic leukemia and a translocation (10;11)(p14;q21). Clinically, the disease was characterized by extreme hypereosinophilia with most eosinophils being immature, pronounced marrow infiltration with abnormal eosinophil precursors, skin and lymphoid infiltration with leukemic eosinophils, and only a brief remission from chemotherapy. This is the second report of a patient with this cytogenetic/clinicopathological association. In our patient, t(10;11)(p14;q21) was the sole karyotypic abnormality seen in the bone marrow, both at diagnosis and relapse. Thus, acute eosinophilic leukemia with t(10;11)(p14;q21) appears to be a rare, new clinical/cytogenetic association. Because both patients with this translocation responded only briefly to chemotherapy, this chromosomal abnormality may confer a poor prognosis.
AuthorsS A Fischkoff, J R Testa, C A Schiffer
JournalLeukemia (Leukemia) Vol. 2 Issue 6 Pg. 394-7 (Jun 1988) ISSN: 0887-6924 [Print] England
PMID3374171 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Topics
  • Adult
  • Chromosome Aberrations (genetics)
  • Chromosome Disorders
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 11
  • Eosinophils
  • Humans
  • Karyotyping
  • Leukemia (drug therapy, genetics)
  • Male
  • Translocation, Genetic

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