Abstract |
We report a patient with acute eosinophilic leukemia and a translocation (10;11)(p14;q21). Clinically, the disease was characterized by extreme hypereosinophilia with most eosinophils being immature, pronounced marrow infiltration with abnormal eosinophil precursors, skin and lymphoid infiltration with leukemic eosinophils, and only a brief remission from chemotherapy. This is the second report of a patient with this cytogenetic/clinicopathological association. In our patient, t(10;11)(p14;q21) was the sole karyotypic abnormality seen in the bone marrow, both at diagnosis and relapse. Thus, acute eosinophilic leukemia with t(10;11)(p14;q21) appears to be a rare, new clinical/cytogenetic association. Because both patients with this translocation responded only briefly to chemotherapy, this chromosomal abnormality may confer a poor prognosis.
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Authors | S A Fischkoff, J R Testa, C A Schiffer |
Journal | Leukemia
(Leukemia)
Vol. 2
Issue 6
Pg. 394-7
(Jun 1988)
ISSN: 0887-6924 [Print] England |
PMID | 3374171
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Topics |
- Adult
- Chromosome Aberrations
(genetics)
- Chromosome Disorders
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 11
- Eosinophils
- Humans
- Karyotyping
- Leukemia
(drug therapy, genetics)
- Male
- Translocation, Genetic
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