Interferon induces cell fusion and the formation of multinuclear cells in a culture of Ehrlich ascites tumor cells.

Abstract

The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi- or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell.

• Authors: S Tominaga
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 135 Issue 2 Pg. 350-4 (May 1988) ISSN: 0021-9541 [Print] United States
• PMID: 3372601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interferon Type I
• Recombinant Proteins

Topics

• Animals
• Carcinoma, Ehrlich Tumor (pathology)
• Cell Division (drug effects)
• Cell Fusion (drug effects)
• Cell Nucleus (drug effects, ultrastructure)
• Interferon Type I (physiology)
• Kinetics
• Mice
• Recombinant Proteins (pharmacology)