Interferon induces cell fusion and the formation of multinuclear cells in a culture of Ehrlich ascites tumor cells.

The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi- or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell.
AuthorsS Tominaga
JournalJournal of cellular physiology (J Cell Physiol) Vol. 135 Issue 2 Pg. 350-4 (May 1988) ISSN: 0021-9541 [Print] UNITED STATES
PMID3372601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon Type I
  • Recombinant Proteins
  • Animals
  • Carcinoma, Ehrlich Tumor (pathology)
  • Cell Division (drug effects)
  • Cell Fusion (drug effects)
  • Cell Nucleus (drug effects, ultrastructure)
  • Interferon Type I (physiology)
  • Kinetics
  • Mice
  • Recombinant Proteins (pharmacology)

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