Opinion: miRNAs - The new wave of molecular cancer therapeutics.

Abstract

Cutting-edge advances in nanomedicine and the recent approval of two siRNA-based therapeutics by the Food and Drug Administration (FDA) has rekindled the interest in RNA interference (RNAi) as vehicles for the development of novel cancer therapeutics. In this perspective, we will briefly discuss how miRNAs are becoming the next-generation RNAi therapeutic, the advances in delivery vehicles for in vivo miRNA delivery, and where miRNA technology stands in terms of clinical translation.

• Authors: Hernando Lopez-Bertoni, John Laterra
• Journal: Translational oncology (Transl Oncol) Vol. 14 Issue 6 Pg. 101064 (Jun 2021) ISSN: 1936-5233 [Print] United States
• PMID: 33721829 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier Inc.