[The effects of TMB-8, an intracellular Ca2+ antagonist, on impaired left ventricular relaxation by global ischemia in dog].

Abstract

The effects of TMB-8, an inhibitor of Ca2+ release from the intracellular store site, on impaired left ventricular relaxation caused by global ischemia were examined in 45 anesthetized dogs. In the non-ischemic group, the intracoronary infusion of 100 micrograms/min TMB-8 suppressed the decrease in T, an index of left ventricular relaxation, by increasing the atrial pacing rate. In the ischemic group, the intracoronary infusion of 30 and 100 micrograms/min TMB-8 suppressed the increases of T and left ventricular end-diastolic pressure caused by ischemia and increase of pacing rate. The results indicate that TMB-8 suppresses the ability of relaxation in non-ischemic myocardium and prevents the impairment of left ventricular relaxation induced by left ventricular global ischemia.

• Authors: H Sonoki, Y Uchida, T Tomaru, T Sugimoto
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 91 Issue 3 Pg. 141-50 (Mar 1988) ISSN: 0015-5691 [Print] Japan
• PMID: 3371798 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• Calmodulin
• 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate
• Gallic Acid

Topics

• Animals
• Calcium Channel Blockers (pharmacology)
• Calmodulin (antagonists & inhibitors)
• Dogs
• Gallic Acid (analogs & derivatives, pharmacology)
• Heart Rate (drug effects)
• Heart Ventricles
• Hemodynamics (drug effects)
• Ischemia (physiopathology)
• Myocardial Contraction (drug effects)
• Sarcoplasmic Reticulum (metabolism)