[Tetralogy of Fallot following coumarin administration in early pregnancy--an embryopathy?].

Abstract

A case report of a 35-year old woman is presented who continued a coumarin therapy unconscious of an early pregnancy up to day 61. At term she delivered a baby with tetralogy of Fallot, up to now not mentioned in the symptom complex of malformations due to a coumarin therapy. In the case presented the typical symptoms of a warfarin embryopathy including a chondrodysplasia punctata and other morphological changes were lacking. Although some cases of cardiac malformations have been reported in literature following coumarin therapy in early pregnancy, a causal connection could not be confirmed.

• Authors: M D Balde, G P Breitbach, A Wettstein, W Hoffmann, G Bastert
• Journal: Geburtshilfe und Frauenheilkunde (Geburtshilfe Frauenheilkd) Vol. 48 Issue 3 Pg. 182-3 (Mar 1988) ISSN: 0016-5751 [Print] Germany
• Vernacular Title: Fallotsche Tetralogie nach Cumarineinnahme in der Frühschwangerschaft--eine Embryopathie?
• PMID: 3371633 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• 4-Hydroxycoumarins
• Phenprocoumon

Topics

• 4-Hydroxycoumarins (adverse effects)
• Adult
• Echocardiography
• Female
• Humans
• Infant, Newborn
• Phenprocoumon (administration & dosage, adverse effects)
• Pregnancy
• Pregnancy Complications, Cardiovascular (drug therapy)
• Pregnancy Trimester, First
• Tetralogy of Fallot (chemically induced)
• Thrombophlebitis (drug therapy)