Abstract | STUDY OBJECTIVES: METHODS: We retrospectively reviewed the medical records of patients with sleep-related eating disorder/ night eating syndrome at the Yoyogi Sleep Disorder Center from November 2013 to November 2018. We categorized patients as ramelteon treatment responders when the frequency of nighttime eating per week decreased to less than half of that before treatment. RESULTS: Forty-nine patients were included in the analysis. The mean frequency of eating behavior (per week) (standard deviation) at baseline and post- ramelteon treatment was significantly different, at 5.3 (2.2) and 3.2 (3.0), respectively (P < .001). Twenty-one patients (42.9%) were classified as responders. Adverse events, all of which were mild daytime somnolence, were observed in 5 patients. There were significantly more individuals using benzodiazepine derivatives and Z-drugs before treatment and those with coexisting delayed sleep-wake phase disorder in the responder group than in the nonresponder group (P < .001 and P < .05, respectively). The mean benzodiazepine derivatives and Z-drugs dose significantly decreased from baseline to post- ramelteon treatment within the responder group (P < .05). This trend was not observed in the nonresponder group. Meanwhile, the sleep midpoint of patients with sleep-related eating disorder/ night eating syndrome and delayed sleep-wake phase disorder did not significantly change after treatment. CONCLUSIONS:
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Authors | Kentaro Matsui, Kenichi Kuriyama, Mina Kobayashi, Ken Inada, Katsuji Nishimura, Yuichi Inoue |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 17
Issue 7
Pg. 1475-1483
(07 01 2021)
ISSN: 1550-9397 [Electronic] United States |
PMID | 33704048
(Publication Type: Journal Article)
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Copyright | © 2021 American Academy of Sleep Medicine. |
Chemical References |
- Indenes
- Pharmaceutical Preparations
- Benzodiazepines
- ramelteon
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Topics |
- Benzodiazepines
- Drug Tapering
- Feeding and Eating Disorders
(complications, drug therapy)
- Humans
- Indenes
- Night Eating Syndrome
- Pharmaceutical Preparations
- Retrospective Studies
- Sleep
- Sleep Initiation and Maintenance Disorders
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