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[Pharmacokinetics of dalargin].

Abstract
Pharmacokinetics of a new anti-ulcer drug, synthetic opioid hexapeptide dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg), which is an analogue of Leu-enkephalin, was studied in rats. Distribution and metabolism of 3H-Tyr-dalargin were examined after intravenous administration at a dose of 150 mg/kg. Main Tyr-containing metabolites of dalargin were detected and dynamics of their concentrations was evaluated in blood within 1 hr after administration. Kinetic curve of dalargin was described as three-exponential function.
AuthorsE I Kalenikova, O F Dmitrieva, N V Korobov, S V Zhukovskiĭ, V A Tishchenko
JournalVoprosy meditsinskoi khimii (Vopr Med Khim) 1988 Jan-Feb Vol. 34 Issue 1 Pg. 75-83 ISSN: 0042-8809 [Print] Russia (Federation)
Vernacular TitleFarmakokinetika dalargina.
PMID3369130 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Enkephalin, Leucine
  • Enkephalin, Leucine-2-Alanine
  • enkephalin-Leu, Ala(2)-Arg(6)-
Topics
  • Animals
  • Anti-Ulcer Agents (blood, pharmacokinetics, urine)
  • Chromatography, High Pressure Liquid
  • Enkephalin, Leucine (analogs & derivatives, blood, pharmacokinetics, urine)
  • Enkephalin, Leucine-2-Alanine (analogs & derivatives)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution

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