Association between Hyperhomocysteinemia and Hypertensive Retinopathy in a Chinese Han Population.

Abstract

Purpose/aim: In some diseases, hyperhomocysteinemia (HHcy) has been recognized as a risk factor. However, information on the correlation between HHcy and hypertensive retinopathy (HR) in the Chinese population is unclear. We, therefore, aimed to investigate this association.Materials and Methods: A total of 382 patients were collected and 126 individuals were excluded in this study. Finally, 128 patients with HR and 128 control subjects were enrolled sequentially. The association between HHcy and the occurrence of HR was determined by multivariate logistic regression analysis, including interaction and stratified analyses.Results: HHcy, cardiovascular disease, fasting blood glucose, creatinine, triglyceride, diabetes, smoking habits, drinking habits were significantly associated with HR (P < .05) in the univariate logistic regression analysis. Each increase of 1 μmol/L of homocysteine concentration was significantly correlated with a 9% increased risk of HR (odds ratio [OR] = 1.09, 95% confidence interval [CI]: 1.07-1.55, P < .05). Hierarchical analysis identified history of diabetes (OR = 7.38, P > .05), age ≥60 years (OR = 3.08, P > .05), male sex (OR = 1.04, P > .05), history of cardiovascular disease (OR = 7.88, P > .05), smoking habit (OR = 1.08, P > .05), and drinking habit (OR = 78.31, P > .05), as factors associated with HR, but not as independent risk factors for HR. Interaction analysis demonstrated no interaction between HHcy and HR.Conclusions: Within the Chinese Han population, HHcy is an independent risk factor for HR.

• Authors: Ze-Long Zhong, Jie Liu
• Journal: Current eye research (Curr Eye Res) Vol. 46 Issue 10 Pg. 1539-1543 (10 2021) ISSN: 1460-2202 [Electronic] England
• PMID: 33660574 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Triglycerides
• Homocysteine
• Creatinine

Topics

• Aged
• Asian People (ethnology)
• Blood Glucose (metabolism)
• Case-Control Studies
• China (epidemiology)
• Creatinine (blood)
• Female
• Homocysteine (blood)
• Humans
• Hyperhomocysteinemia (epidemiology)
• Hypertensive Retinopathy (epidemiology)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Risk Factors
• Triglycerides (blood)