Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells.
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| Abstract |
Organisms use l-amino acids (l-aa) for most physiological processes. Unlike other organisms, bacteria chiral-convert l-aa to d-configurations as essential components of their cell walls and as signaling molecules in their ecosystems. Mammals recognize microbe-associated molecules to initiate immune responses, but roles of bacterial d-amino acids (d-aa) in mammalian immune systems remain largely unknown. Here, we report that amino acid chirality balanced by bacteria-mammal cross-talk modulates intestinal B cell fate and immunoglobulin A (IgA) production. Bacterial d-aa stimulate M1 macrophages and promote survival of intestinal naïve B cells. Mammalian intestinal d-aa catabolism limits the number of B cells and restricts growth of symbiotic bacteria that activate T cell-dependent IgA class switching of the B cells. Loss of d-aa catabolism results in excessive IgA production and dysbiosis with altered IgA coating on bacteria. Thus, chiral conversion of amino acids is linked to bacterial recognition by mammals to control symbiosis with bacteria.
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| Authors | Masataka Suzuki, Tomohisa Sujino, Sayako Chiba, Yoichi Harada, Motohito Goto, Riichi Takahashi, Masashi Mita, Kenji Hamase, Takanori Kanai, Mamoru Ito, Matthew Kaden Waldor, Masato Yasui, Jumpei Sasabe |
| Journal | Science advances (Sci Adv) Vol. 7 Issue 10 (03 2021) ISSN: 2375-2548 [Electronic] United States |
| PMID | 33658193 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
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