Abstract | OBJECTIVE: DATA SOURCES: The following PubMed literature search terms were used from July 2020 to January 2, 2021: diabetes, COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), glucose-lowering agents, and pharmacology. STUDY SELECTION AND DATA EXTRACTION: English-language studies reporting on the association between diabetes, COVID-19 adverse outcomes, and the potential roles of glucose-lowering agents were reviewed. DATA SYNTHESIS: RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE: CONCLUSIONS: Certain glucose-lowering agents may offer additional benefits beyond glucose control-namely, by modulating the mechanisms contributing to adverse outcomes related to COVID-19 in patients with diabetes. DPP-IV inhibitors and metformin appear to have the most promise. However, current published literature on diabetes medications and COVID-19 should be interpreted with caution. Most published studies are retrospective and consist of convenience samples, and some lack adequate analytical approaches with confounding biases. Ongoing trials aim to evaluate the effects of glucose-lowering agents in reducing the severity of COVID-19 outcomes.
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Authors | Helen D Berlie, Pramodini B Kale-Pradhan, Tara Orzechowski, Linda A Jaber |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 55
Issue 11
Pg. 1386-1396
(11 2021)
ISSN: 1542-6270 [Electronic] United States |
PMID | 33657863
(Publication Type: Journal Article, Review)
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Chemical References |
- Dipeptidyl-Peptidase IV Inhibitors
- Hypoglycemic Agents
- Glucose
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Topics |
- COVID-19
- Diabetes Mellitus, Type 2
(drug therapy)
- Dipeptidyl-Peptidase IV Inhibitors
- Glucose
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Retrospective Studies
- SARS-CoV-2
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