A major inhibitor of phenytoin binding to serum protein in uremia.

Abstract

A major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), accumulated in the sera of uremic patients, inhibited phenytoin binding to pooled serum obtained from healthy subjects and to human serum albumin in a concentration usually observed in the sera of patients with uremia. This suggests that CMPF is a major drug-binding inhibitor present in uremic serum and may be one of the so-called 'uremic toxins'.

• Authors: H Mabuchi, H Nakahashi
• Journal: Nephron (Nephron) Vol. 48 Issue 4 Pg. 310-4 ( 1988) ISSN: 1660-8151 [Print] Switzerland
• PMID: 3362278 (Publication Type: Journal Article)

Chemical References

• Furans
• Propionates
• Serum Albumin
• Phenytoin
• 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid

Topics

• Adult
• Binding, Competitive
• Furans
• Humans
• In Vitro Techniques
• Male
• Middle Aged
• Phenytoin (blood)
• Propionates (blood)
• Protein Binding (drug effects)
• Serum Albumin (metabolism)
• Uremia (blood)