1-Aryl-3-(2-chloroethyl) ureas: synthesis and in vitro assay as potential anticancer agents.

Abstract

1-Aryl-3-(2-chloroethyl) ureas and 1-aryl-3-nitroso-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanilines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitroso derivatives were inactive.

• Authors: R C Gaudreault, J Lacroix, M Pagé, L P Joly
• Journal: Journal of pharmaceutical sciences (J Pharm Sci) Vol. 77 Issue 2 Pg. 185-7 (Feb 1988) ISSN: 0022-3549 [Print] United States
• PMID: 3361435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Nitrosourea Compounds

Topics

• Adenocarcinoma (drug therapy)
• Antineoplastic Agents (chemical synthesis)
• Drug Screening Assays, Antitumor
• Humans
• Nitrosourea Compounds (chemical synthesis, pharmacology)
• Tumor Cells, Cultured (drug effects)