A prospective, randomized, controlled, crossover study comparing three multilayered foam dressings for the management of chronic wounds.

Abstract

Aim: Compare foam dressings - Mepilex Border Flex (MxBF), Allevyn Life (AL) and Optifoam Gentle EX (OGEX) - in treatment of chronic wounds. Materials & methods: Prospective, randomized, controlled trial (crossover design). Subjects received one dressing for 2 weeks, then comparator dressing for following 2 weeks. Wound/periwound characteristics evaluated weekly at dressing change. Primary end point: dressing durability (incidence of exudate strikethrough). Results: Higher incidence of intact dressings (no strikethrough) at Day 7 (Week 1) with MxBF (6/17; 35.3%) compared with AL (1/18; 5.6%), and with MxBF (7/16; 43.8%) compared with OGEX (2/16; 12.5%; p < 0.05). No significant differences between groups regarding wound size reduction. Conclusion: MxBF had statistically greater durability than AL/OGEX during first critical week of treatment.

• Authors: Oscar M Alvarez, Mark S Granick, Alexander Reyzelman, Thomas Serena
• Journal: Journal of comparative effectiveness research (J Comp Eff Res) Vol. 10 Issue 6 Pg. 481-493 (04 2021) ISSN: 2042-6313 [Electronic] England
• PMID: 33605157 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Topics

• Bandages
• Cross-Over Studies
• Humans
• Occlusive Dressings
• Prospective Studies
• Wound Healing