A Novel Targeted Therapy System for Cervical Cancer:  Co-Delivery System  of  Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier.

Abstract

BACKGROUND:

This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplatin (OXA) and antisense lncRNA of MDC1 (MDC1-AS) to Cervical cancer cells and evaluate the efficiency of this drug carrier and its antitumor effects on Cervical cancer.

METHODS:

Thermosensitive magnetic cationic liposomes were prepared using thin-film hydration method. The OXA and MDC1-AS vectors were loaded into the codelivery system, and the in vitro OXA thermosensitive release activity, efficiency of MDC1-AS regulating MDC1, in vitro cytotoxicity, and in vivo antitumor activity were determined.

RESULTS:

The codelivery system had desirable targeted delivery efficacy, OXA thermosensitive release, and MDC1-AS regulating MDC1. Codelivery of OXA and MDC1-AS enhanced the inhibition of cervical cancer cell growth in vitro and in vivo, compared with single drug delivery.

CONCLUSION:

The novel codelivery of OXA and MDC1-AS magnetic thermosensitive cationic liposome drug carrier can be applied in the combined chemotherapy and gene therapy for cervical cancer.

• Authors: Hui Ye, Xiaoying Chu, Zhensheng Cao, Xuanxuan Hu, Zihan Wang, Meiqi Li, Leyu Wan, Yongping Li, Yongge Cao, Zhanqiu Diao, Fengting Peng, Jinsong Liu, Lihua Xu
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 16 Pg. 1051-1066 ( 2021) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 33603368 (Publication Type: Journal Article)
• Copyright: © 2021 Ye et al.

Chemical References

• Adaptor Proteins, Signal Transducing
• Cations
• Cell Cycle Proteins
• Drug Carriers
• Liposomes
• MDC1 protein, human
• RNA, Long Noncoding
• Oxaliplatin

Topics

• Adaptor Proteins, Signal Transducing (genetics)
• Animals
• Apoptosis (drug effects, genetics)
• Cations
• Cell Cycle Proteins (genetics)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Proliferation (drug effects, genetics)
• Drug Carriers (chemistry)
• Drug Delivery Systems
• Drug Liberation
• Female
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Liposomes
• Magnetic Phenomena
• Mice, Inbred BALB C
• Mice, Nude
• Molecular Targeted Therapy
• Oxaliplatin (pharmacology, therapeutic use)
• Particle Size
• RNA, Long Noncoding (administration & dosage)
• Static Electricity
• Temperature
• Uterine Cervical Neoplasms (genetics, pathology, therapy)
• Mice