HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of the vasodilator trimazosin versus placebo on exercise performance in chronic left ventricular failure.

Abstract
The effect of the vasodilator trimazosin versus placebo on exercise duration until marked dyspnea was evaluated in a double blind randomized study in 16 patients with chronic left ventricular failure despite digitalis and diuretic therapy. Trimazosin caused a reduction in resting systolic and diastolic blood pressures and in resting product of systolic blood pressure times heart rate. The improvement in exercise duration from the average of values during the baseline and single blind placebo periods was greater after 3 and 6 weeks of trimazosin therapy (300 and 450 mg daily) after 3 and 6 weeks of double blind placebo therapy (P is less than 0.025). Four of eight patients receiving trimazosin had disappearance of pulmonary venous congestion on chest roentgenography compared with none of eight patients receiving placebo. These preliminary data suggest that trimazosin may be effective in treating chronic left ventricular failure.
AuthorsW S Aronow, R S Greenfield, H Alimadadian, D T Danahy
JournalThe American journal of cardiology (Am J Cardiol) Vol. 40 Issue 5 Pg. 789-93 (Nov 1977) ISSN: 0002-9149 [Print] United States
PMID335867 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Piperazines
  • Placebos
  • Quinazolines
  • Vasodilator Agents
  • trimazosin
Topics
  • Adult
  • Aged
  • Blood Pressure (drug effects)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Exercise Test
  • Heart Failure (drug therapy)
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Physical Exertion
  • Piperazines (therapeutic use)
  • Placebos
  • Quinazolines (therapeutic use)
  • Vasodilator Agents (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: