Reassignment of the structure for the antitumor agent RR-150.

Abstract

7-Cysteaminomitosane (RR-150) has been reported to be superior to mitomycin C against P388 leukemia and B-16 melanoma in mice and is less leukopenic. Studies reported here indicated the absence of a free thiol group in RR-150 and therefore the structure was incorrectly assigned. Reaction of mitomycin A with either 2-aminoethanethiol or cystamine gave the same disulfide, 7-N,7'-N'-dithiodiethylenedimitomycin C, which is the newly proposed structure for RR-150. Attempts to produce 7-cysteaminomitosane by reduction of the disulfide have not succeeded because of its apparent instability.

• Authors: P D Senter, D R Langley, W E Manger, D M Vyas
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 2 Pg. 199-201 (Feb 1988) ISSN: 0021-8820 [Print] England
• PMID: 3356608 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Mitomycins
• 7-cysteaminomitosane

Topics

• Antibiotics, Antineoplastic (chemical synthesis)
• Chemical Phenomena
• Chemistry
• Mitomycins (chemical synthesis)