Abstract |
The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. On repeated i.v. injection of 200 mg kg-1 every 4 days FAA was moderately active against the s.c. growing HCC-P2988. HCC-M1410 transplanted s.c. was almost unresponsive in the same experimental conditions. In contrast, FAA (200 mg kg-1 i.v. every 4 days, repeated three times) significantly reduced liver tumour colonies produced by the HCC-M1410 cells injected intrasplenically into nude mice. These findings suggest that FAA has potential activity against human colorectal carcinoma, particularly against liver metastases.
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Authors | R Giavazzi, A Garofalo, G Damia, S Garattini, M D'Incalci |
Journal | British journal of cancer
(Br J Cancer)
Vol. 57
Issue 3
Pg. 277-80
(Mar 1988)
ISSN: 0007-0920 [Print] England |
PMID | 3355765
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Flavonoids
- flavone acetic acid
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Flavonoids
(therapeutic use)
- Humans
- Liver Neoplasms
(drug therapy, secondary)
- Male
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Rectal Neoplasms
(drug therapy)
- Transplantation, Heterologous
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