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[Effect of a newly developed platinum compound cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II), on human ovarian tumors transplanted into nude mice].

Abstract
The therapeutic effect of cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II) (NK 121) on 3 human yolk sac tumors of the ovary (YST-1, YST-2 and YST-3), which were transplanted into nude mice, was compared with that of cisplatin (CDDP). While tumors YST-2 and YST-3 exhibited a broad comparable sensitivity to CDDP and NK 121, YST-1 was substantially more sensitive to CDDP than NK 121. A significant weight loss was noted in the non-tumor bearing nude mice treated with CDDP, as compared with the loss in both control and NK 121-treated groups. NK 121 showed a good antitumor activity without showing severe toxicities.
AuthorsM Sawada, M Ozaki, H Taniguchi, R Tateishi, Y Mori, K Mino
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 15 Issue 4 Pt 1 Pg. 637-41 (Apr 1988) ISSN: 0385-0684 [Print] Japan
PMID3355185 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Organoplatinum Compounds
  • NK 121
  • Carboplatin
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Carboplatin (analogs & derivatives)
  • Female
  • Humans
  • Mesonephroma (drug therapy, pathology)
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Organoplatinum Compounds (therapeutic use)
  • Ovarian Neoplasms (drug therapy, pathology)

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