Bifenazate exposure induces cardiotoxicity in zebrafish embryos.

Abstract

Bifenazate is a novel acaricide for selective foliar spraying and is widely used to control mites in agricultural production. However, its toxicity to aquatic organisms is unknown. Here, a zebrafish model was used to study bifenazate toxicity to aquatic organisms. Exposure to bifenazate was found to cause severe cardiotoxicity in zebrafish embryos, along with disorders in the gene expression related to heart development. Bifenazate also caused oxidative stress. Cardiotoxicity caused by bifenazate was partially rescued by astaxanthin (an antioxidant), accompanied by cardiac genes and oxidative stress-related indicators becoming normalized. Our results showed that exposure to bifenazate can significantly change the ATPase activity and gene expression levels of the calcium signaling pathway. These led to heart failure, in which the blood accumulated outside the heart without entering it, eventually leading to death. The results indicated that bifenazate exposure caused cardiotoxicity in zebrafish embryos through the induction of oxidative stress and inhibition of the calcium signaling pathway.

• Authors: Jinze Ma, Yong Huang, Yuyang Peng, Zhaopeng Xu, Ziqin Wang, Xiaobei Chen, Shuling Xie, Ping Jiang, Keyuan Zhong, Huiqiang Lu
• Journal: Environmental pollution (Barking, Essex : 1987) (Environ Pollut) Vol. 274 Pg. 116539 (Apr 01 2021) ISSN: 1873-6424 [Electronic] England
• PMID: 33549839 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Carbamates
• Hydrazines
• bifenazate

Topics

• Animals
• Carbamates (metabolism)
• Cardiotoxicity (metabolism)
• Embryo, Nonmammalian (metabolism)
• Hydrazines
• Oxidative Stress
• Zebrafish