Heart
angiosarcoma, the most frequent among cardiac
malignancies, is an extremely rare vascular
tumor known to carry a dismal prognosis. The spectrum of presenting symptoms depends on
tumor's size, its anatomic location, and its invasiveness, whereas imaging techniques including cardiac magnetic resonance are critical in the differential diagnosis between malignant and
benign neoplasms. Despite there are various available systemic therapeutic regimens for advanced cardiac
angiosarcomas, yet, it still remains unclear which of them offers the best survival outcome in general. We present the uncommon case of metastatic right atrium
angiosarcoma in a young male patient, in which the combination of
propranolol and weekly
paclitaxel, as first-line treatment, showed promising activity with manageable toxicity. Given the existing strong rationale for repurposing
propranolol in oncology, this therapeutic approach merits further investigation in prospective studies with heart
angiosarcoma patients.