Abstract | OBJECTIVE: DESIGN: Prospective uncontrolled multicentre study. METHODS: One hundred and six patients with LPR have been recruited from 3 European Hospitals. According to the reflux characteristics at the impedance-pH monitoring ( acid, non- acid, mixed, GERD), patients received a personalised treatment based on the association of diet, pantoprazole, alginate or magaldrate for 3 months. Reflux Symptom Score (RSS) was assessed at baseline, 6 and 12 weeks post-treatment. Reflux Sign Assessment (RSA) has been used to rate laryngeal and extra-laryngeal findings at baseline and 12 weeks post-treatment. Overall success rate and the evolution of symptoms and findings were evaluated according to the LPR types. RESULTS: One hundred and two LPR patients (42 acid, 33 non- acid, 27 mixed, including 49 with LPR and GERD) completed the study. RSS and RSA total scores significantly improved from baseline to post-treatment time in acid, mixed and non- acid groups. The presence of GERD in addition to LPR did not impact the clinical improvement. The 3-month success rates of treatment ranged from 62% to 64%, and there were no significant differences between groups. The success rate of patients with non- acid LPR was similar to those of patients with mixed and acid LPR. CONCLUSION: MII-pH is useful to specify the type of LPR and the related most adequate therapeutic regimen. Non- acid or mixed LPR similarly respond to treatment than acid LPR but require a treatment based on alginate or magaldrate covering the non- acid proximal reflux events.
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Authors | Jérôme R Lechien, Francois Bobin, Vinciane Muls, Francois Mouawad, Didier Dequanter, Mihaela Horoi, Marie-Paule Thill, Alexandra Rodriguez Ruiz, Sven Saussez |
Journal | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
(Clin Otolaryngol)
Vol. 46
Issue 3
Pg. 602-613
(May 2021)
ISSN: 1749-4486 [Electronic] England |
PMID | 33503317
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2021 John Wiley & Sons Ltd. |
Topics |
- Belgium
- Electric Impedance
- Endoscopy, Gastrointestinal
- Esophageal pH Monitoring
- Female
- France
- Humans
- Laryngopharyngeal Reflux
(therapy)
- Male
- Middle Aged
- Precision Medicine
- Prospective Studies
- Severity of Illness Index
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