Abstract |
Serum and tonsillary tissue levels of cefroxadine, a new broad-spectrum cephalosporin, proving to be effective in several infections, particularly in the ENT ones, were measured in patients scheduled for tonsillectomy. Twenty patients (12 males, 8 females) aged between 11 and 25 years (mean 18.0 years) were given cefroxadine for 2 days (500 mg every 12 h), and on the 3rd day 500 mg of the drug was given before surgical operation. Tonsillar tissues were taken 2 h after dosing and blood samples before, 1, 2, 4 and 6 h after the drug administration in 8 out of 20 enrolled patients. Cefroxadine concentrations were measured according to microbiological methods. Cefroxadine tonsillary levels were 1.13 +/- 1.73 micrograms/g, approaching the MIC for sensitive bacteria. The time course of plasma levels is superimposable to previous studies. These findings suggest a rapid penetration of cefroxadine in tonsillar tissue and seem to confirm the clinical efficacy of the drug in ENT infections.
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Authors | F Fraschini, F Scaglione, F Vago, E Bichisao, C Borghi, M Montanari |
Journal | Chemotherapy
(Chemotherapy)
Vol. 34
Issue 1
Pg. 8-12
( 1988)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 3349862
(Publication Type: Journal Article)
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Chemical References |
- Cephalosporins
- cefroxadine
- Cephradine
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Topics |
- Adolescent
- Adult
- Cephalosporins
(pharmacokinetics)
- Cephradine
(analogs & derivatives, blood, pharmacokinetics)
- Child
- Female
- Humans
- Male
- Palatine Tonsil
(metabolism)
- Premedication
- Tonsillitis
(drug therapy, surgery)
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