Abstract |
The rates of remission after a course of antithyroid drugs in 71 black and 45 white patients with Graves' disease were compared. One year after stopping therapy 27% of blacks and 47% of whites were in remission (P less than 0.01); at 2 years the proportions were 7% and 27% respectively (P less than 0.05). Small size of goitre only was a weak predictor of remission; duration of therapy did not influence the outcome. HLA A2 and B17 may be less frequent in black patients who remain in remission (P = 0.048 and 0.067 respectively). The data suggest that it is not worth while undertaking a trial of medical therapy in unselected black patients with Graves' disease.
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Authors | W J Kalk, M Berzin, J Wing |
Journal | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
(S Afr Med J)
Vol. 73
Issue 5
Pg. 284-6
(Mar 05 1988)
ISSN: 0256-9574 [Print] South Africa |
PMID | 3347882
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Black People
- Carbimazole
(administration & dosage, therapeutic use)
- Female
- Graves Disease
(drug therapy)
- Humans
- Male
- Middle Aged
- Remission Induction
- White People
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