HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Treatment of acute hepatic porphyria with hematin.

Abstract
The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks. The clinical response to hematin occurred uniformly on the third or fourth day of treatment, suggesting that a stereotypic response to this form of therapy can be defined. Hematin had no effect on chronic subacute symptoms. The indications for hematin therapy, its rationale and the details of its administration are reviewed.
AuthorsD M Bissell
JournalJournal of hepatology (J Hepatol) Vol. 6 Issue 1 Pg. 1-7 (Feb 1988) ISSN: 0168-8278 [Print] Netherlands
PMID3346530 (Publication Type: Journal Article)
Chemical References
  • Heme
  • Hemin
  • Porphobilinogen
  • Aminolevulinic Acid
Topics
  • Acute Disease
  • Adult
  • Aged
  • Aminolevulinic Acid (urine)
  • Female
  • Heme (analogs & derivatives)
  • Hemin (therapeutic use)
  • Humans
  • Liver Diseases (drug therapy, urine)
  • Male
  • Middle Aged
  • Porphobilinogen (urine)
  • Porphyrias (drug therapy, urine)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: