Abstract |
A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as blasticidin S, demonstrated anti-inflammatory activity in the reverse passive Arthus reaction and the adjuvant arthritic rat at doses ranging between 1-10 mg/kg and 0.3-6.0 mg/kg, respectively. A minor component, Sch 366606, co-produced in the in the fermentation was isolated and identified as a known compound in the blasticidin family of compounds.
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Authors | V Gullo, M Conover, R Cooper, C Federbush, A C Horan, T Kung, J Marquez, M Patel, A Watnick |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 41
Issue 1
Pg. 20-4
(Jan 1988)
ISSN: 0021-8820 [Print] England |
PMID | 3346189
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Guanidines
- Nucleosides
- Sch 36605
- blasticidin S
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Topics |
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology)
- Fermentation
- Guanidines
(pharmacology)
- Mice
- Nucleosides
(isolation & purification, pharmacology)
- Rats
- Streptomyces
(classification, metabolism)
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