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Sch 36605, a novel anti-inflammatory compound. Taxonomy, fermentation, isolation and biological properties.

Abstract
A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as blasticidin S, demonstrated anti-inflammatory activity in the reverse passive Arthus reaction and the adjuvant arthritic rat at doses ranging between 1-10 mg/kg and 0.3-6.0 mg/kg, respectively. A minor component, Sch 366606, co-produced in the in the fermentation was isolated and identified as a known compound in the blasticidin family of compounds.
AuthorsV Gullo, M Conover, R Cooper, C Federbush, A C Horan, T Kung, J Marquez, M Patel, A Watnick
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 1 Pg. 20-4 (Jan 1988) ISSN: 0021-8820 [Print] England
PMID3346189 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Guanidines
  • Nucleosides
  • Sch 36605
  • blasticidin S
Topics
  • Animals
  • Anti-Inflammatory Agents (isolation & purification, pharmacology)
  • Fermentation
  • Guanidines (pharmacology)
  • Mice
  • Nucleosides (isolation & purification, pharmacology)
  • Rats
  • Streptomyces (classification, metabolism)

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