Metabolism of ether glycolipids with potentially antineoplastic activity by Ehrlich ascites tumor cells.

Abstract

Ehrlich ascites tumor cells were incubated in vitro with rac-1-O-[1'-14C]octadecyl-2-O-methylglycero-3-beta-D-glucopyranosi de for 24 h. The potentially antineoplastic ether glycolipid was rapidly metabolized by the cells to radioactive 1-O-octadecyl-2-O-methylglycerol (70 pmol/10(6) cells per h) and further acylated to 1-O-octadecyl-2-O-methyl-3-acylglycerols. Incubation of Ehrlich ascites cells with synthetic rac-1-O-[1'-14C]octadecyl-2-O-methyl-3-palmitoylglycerol showed that this metabolite is reconverted by deacylation to 14C-labeled 1-O-octadecyl-2-O-methylglycerol. The latter compound or a metabolite derived therefrom may be the 'toxic principle' of both the ether glyceroglycolipids and ether glycerophospholipids having a 1-O-alkyl-2-O-methylglyceryl moiety, as suggested by Unger et al. (J. Natl. Cancer Inst. 78 (1987) 219-222).

• Authors: N Weber, H Benning
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 959 Issue 1 Pg. 91-4 (Mar 04 1988) ISSN: 0006-3002 [Print] Netherlands
• PMID: 3345313 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Carbon Radioisotopes
• Phospholipid Ethers
• 1-O-octadecyl-2-O-methylglycerol-3-glucopyranoside
• Glucose

Topics

• Animals
• Antineoplastic Agents (metabolism)
• Carbon Radioisotopes
• Carcinoma, Ehrlich Tumor (drug therapy, metabolism)
• Glucose (analogs & derivatives, metabolism, therapeutic use)
• Kinetics
• Mice
• Phospholipid Ethers (metabolism, therapeutic use)