Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions.

Abstract

Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor's microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under photothermal conditions, mAb-CD163/Au inhibited tumor invasion by killing M2 macrophages in vitro. After exposure to near-infrared (NIR) laser, mAb-CD163/Au inhibited tumor growth in vivo. The gold nanoparticles were modified to target M2 macrophages. Under NIR laser irradiation, mAb-CD163/Au achieved antitumor effects by killing M2 macrophages in vitro and in vivo.

• Authors: Bo Wang, Ying Huang
• Journal: Lasers in medical science (Lasers Med Sci) Vol. 37 Issue 1 Pg. 299-307 (Feb 2022) ISSN: 1435-604X [Electronic] England
• PMID: 33439377 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd. part of Springer Nature.

Chemical References

• Gold

Topics

• Gold
• Homicide
• Metal Nanoparticles
• Phototherapy
• Tumor-Associated Macrophages