Autocrine growth of murine lymphoma cells.

Abstract

By using an assay system in which small numbers of murine T lymphoma cells are stimulated to grow in serum-free medium, we have continued and expanded our previous studies of an autocrine growth factor that we call leukemia-derived growth factor (LDGF). We show that a T lymphoma cell line of immature phenotype, adapted to growth in serum-free medium, produces and responds to LDGF. LDGF activity is distinct from activities of 10 highly purified or recombinant hematopoietic growth factors including IL-1 and IL-2. However, growth-stimulating activity for the murine lymphoma cells is provided by a partially purified human LDGF.

• Authors: E F Hays, S Kitada, C H Uittenbogaart, J R Reeve Jr
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 80 Issue 2 Pg. 116-21 (Mar 16 1988) ISSN: 0027-8874 [Print] United States
• PMID: 3343687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Culture Media
• Growth Substances
• Intercellular Signaling Peptides and Proteins
• leukemia growth-promoting factor

Topics

• Animals
• Cell Division (drug effects)
• Culture Media
• Growth Substances (analysis, pharmacology)
• Intercellular Signaling Peptides and Proteins
• Lymphoma (pathology)
• Mice
• Tumor Cells, Cultured (drug effects)