Abstract | INTRODUCTION:
Nivolumab, a programmed death-1(PD-1) inhibitor antibody, have demonstrated anti- tumor activity for multiple malignancies. Such immune checkpoint inhibitors induce novel and distinctive adverse effects, which are collectively named immune-related adverse events. Immune-related adverse events can theoretically occur at any part of the body, including the haemopoietic system. Most immune-related adverse events developed within 10 weeks of receiving immunotherapy. Thus far, there is no report of immune thrombocytopenia as an immune-related adverse event developed after discontinuation of immunotherapy. CASE REPORT: MANAGEMENT AND OUTCOME: DISCUSSION: Most immune-related developed 6 months of immunotherapy. Clinicians need to be aware of a clinical diagnostic complex, developing months to years after discontinuation of immunotherapy, which recently is termed delayed immune-related events. This case is the first report of immune checkpoint inhibitors-induced thrombocytopenia that developed nearly 2 months after discontinuation of treatment with nivolumab for metastatic NSCLC. In future clinical practice, patients who have received immune checkpoint inhibitors develop new or unexplained symptom, irrespective of interval post- immunotherapy, immune-related adverse events should be considered.
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Authors | Shengya Fu, Ting Wang, Feng Xu |
Journal | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
(J Oncol Pharm Pract)
Vol. 27
Issue 6
Pg. 1548-1552
(Sep 2021)
ISSN: 1477-092X [Electronic] England |
PMID | 33435825
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
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Topics |
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Humans
- Lung Neoplasms
(drug therapy)
- Male
- Middle Aged
- Nivolumab
(adverse effects)
- Purpura, Thrombocytopenic, Idiopathic
- Thrombocytopenia
(chemically induced)
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