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[New antihypertensive agent of the imidazoline series: 5-fluoro-methyl-imidazolidinylidene-benzamine-monohydrochloride (flutonidin)].

Abstract
A New Antihypertensive of the Imidazoline Series: 5-Fluoro-2-methyl-imidazolidinylidene-benzamine-monohydrochloride. 5-Fluoro-2-methyl-imidazolidinylidene-benzamine-hydrochloride (flutonidin, ST 600), a new antihypertensive imidazoline compound, was tested over 3 weeks in 20 patients with moderate to severe hypertension. Blood pressure was significantly lowered in both supine and upright position. In nearly 2/3 of the patients treated normalization of blood pressure was achieved. Side effects like sedation, dry mouth or orthostatic complaints were present in 30%. Toxic effects were not registered. It is recommended to reduce the dosage slowly especially in the aged to prevent, in part severe findings after abrupt withdrawal.
AuthorsH Brunner, S Djawan, W Dorda, E Penner, G Grabner
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 27 Issue 8 Pg. 1599-604 ( 1977) ISSN: 0004-4172 [Print] Germany
Vernacular TitleEin neues Antihypertensivum der Imidazolinreihe: 5-Fluor-2-methyl-imidazolidinyliden-benzamin-monohydrochlorid (Flutonidin).
PMID334188 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Antihypertensive Agents
  • Imidazoles
  • Toluidines
Topics
  • Adult
  • Aged
  • Antihypertensive Agents (pharmacology, therapeutic use)
  • Blood Pressure (drug effects)
  • Clinical Trials as Topic
  • Drug Evaluation
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy)
  • Imidazoles (pharmacology, therapeutic use)
  • Middle Aged
  • Posture
  • Toluidines (pharmacology, therapeutic use)

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