[Combination use of lentinan with X-ray therapy in a mouse experimental tumor system (Part I). Basic studies].

Abstract

Apparent reduction of leukocyte counts was observed in mice irradiated with 1,500 approximately 3,000 rads of X-ray on the left hind leg. This reduction of leukocyte counts was completely protected by the pre-treatment with lentinan before X-ray irradiation. Suppressive effect of X-ray on the antitumor function of lentinan seems to be weak. When treatment with X-ray irradiation and lentinan was applied for mice bearing solid type sarcoma 180, additive effect was obtained by the combination of lentinan before or after X-ray irradiation.

• Authors: T Shiio, Y Tsuchiya, K Ohishi, T Yoshihama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 15 Issue 2 Pg. 313-7 (Feb 1988) ISSN: 0385-0684 [Print] Japan
• PMID: 3341791 (Publication Type: English Abstract, Journal Article)

Chemical References

• Polysaccharides
• Lentinan

Topics

• Animals
• Combined Modality Therapy
• Female
• Lentinan (administration & dosage)
• Leukopenia (prevention & control)
• Mice
• Mice, Inbred ICR
• Polysaccharides (administration & dosage)
• Radiotherapy Dosage
• Remission Induction
• Sarcoma 180 (pathology, radiotherapy)