The effect of hormones on an uncommon breast disorder pseudoangiomatous stromal hyperplasia: a case report and literature review.

Abstract

Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of the breast, with few cases reported to date. While the etiology of the disease is uncertain, a prevailing theory is that PASH is hormonally responsive, especially in the presence of progesterone. Literature review shows a correlation between PASH development and oral contraceptive pill (OCP) use. We report a case of a 28-year-old autistic female who underwent excision of palpable bilateral breast masses where the histology of the left breast mass identified as PASH. Our patient had a history of multiple medications including OCPs and cytochrome p450 inhibitors that could lead to an increase in progesterone levels. Thus, supporting a theory that medications, in addition to OCPs, may lead to an increased occurrence of PASH in pre-menopausal women.

• Authors: Genevieve Hattingh, Mariam Ibrahim, Thomas Robinson, Ajay Shah
• Journal: Journal of surgical case reports (J Surg Case Rep) Vol. 2020 Issue 12 Pg. rjaa514 (Dec 2020) ISSN: 2042-8812 [Print] England
• PMID: 33391644 (Publication Type: Journal Article)
• Copyright: Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.