Corneal toxicity of propamidine.

Abstract

Two patients with Acanthamoeba keratitis developed a corneal abnormality following prolonged treatment with topical 0.1% [corrected] propamidine isethionate. In both instances, withdrawal of drug therapy resulted in a gradual clearing of the keratopathy, with no permanent sequelae. The changes we observed may be confused with those of active Acanthamoeba infection.

• Authors: K J Johns, W S Head, D M O'Day
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 106 Issue 1 Pg. 68-9 (Jan 1988) ISSN: 0003-9950 [Print] United States
• PMID: 3337709 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amidines
• Benzamidines
• propamidine isethionate

Topics

• Acanthamoeba
• Administration, Topical
• Adult
• Amebiasis (drug therapy)
• Amidines (adverse effects)
• Animals
• Benzamidines (administration & dosage, adverse effects, therapeutic use)
• Corneal Diseases (chemically induced, pathology)
• Cysts (chemically induced)
• Female
• Humans
• Keratitis (etiology)
• Male