Epilepsy is a common neurological disease that is not always controlled, and the
ketogenic diet shows good
antiepileptic effects
drug-resistant epilepsy or
seizures caused by specific metabolic defects via regulating the metabolism. The brain is a vital organ with high metabolic demands, and epileptic foci tend to exhibit high metabolic characteristics. Accordingly, there has been growing interest in the relationship between brain metabolism and
epilepsy in recent years. To date, several new
antiepileptic therapies targeting metabolic pathways have been proposed (i.e., inhibiting glycolysis, targeting
lactate dehydrogenase, and dietary
therapy). Promising strategies to treat
epilepsy via modulating the brain's metabolism could be expected, while a lack of thorough understanding of the role of brain metabolism in the control of
epilepsy remains. Herein, this review aims to provide insight into the state of the art concerning the brain's metabolic patterns and their association with
epilepsy. Regulation of neuronal excitation via metabolic pathways and
antiepileptic therapies targeting metabolic pathways are emphasized, which could provide a better understanding of the role of metabolism in
epilepsy and could reveal potential therapeutic targets.