Abstract |
The activity of natural ( leukocyte) interferon alfa in the treatment of condylomata acuminata was assessed in a randomized, double-blind, placebo-controlled, multicenter trial. Interferon alfa (Alferon N Injection) or placebo was injected into lesions twice weekly for up to eight weeks. Eighty-six patients were given interferon alfa, and 72 were given placebo. Eighty-six percent of interferon alfa-treated patients and 89% of placebo-treated patients had received previous therapy for condylomata acuminata. Side effects, usually flulike symptoms, occurred briefly after the injections; if present, they disappeared before the end of the third week of therapy. Treatment completely eliminated warts in 62% of interferon alfa-treated patients compared with only 21% of placebo-treated patients. Natural interferon alfa given intralesionally is an effective and safe treatment even in patients with recurrent or recalcitrant genital warts.
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Authors | A E Friedman-Kien, L J Eron, M Conant, W Growdon, H Badiak, P W Bradstreet, D Fedorczyk, J R Trout, T F Plasse |
Journal | JAMA
(JAMA)
1988 Jan 22-29
Vol. 259
Issue 4
Pg. 533-8
ISSN: 0098-7484 [Print] United States |
PMID | 3336177
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Condylomata Acuminata
(therapy)
- Double-Blind Method
- Drug Evaluation
- Female
- Fever
(etiology)
- Genital Neoplasms, Female
(therapy)
- Genital Neoplasms, Male
(therapy)
- Humans
- Influenza, Human
(etiology)
- Interferon Type I
(adverse effects, therapeutic use)
- Leukocyte Count
- Male
- Random Allocation
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