Abstract |
A series of metallopurpurins was tested for their photodynamic activity against transplantable N-[4-(5-nitro-2-furyl)-2-thiazoyl] formamide-induced urothelial tumors growing in male Fischer CDF (F344/CrlBR) rats. Histological examination of tumors in animals treated with the metallopurpurins and red light (greater than 590 nm, 360 J/cm2) revealed tumor necrosis 24 h after completion of therapy. Control tumors showed no histological change. In 30-day tumor regrowth studies, 70% of animals treated with the metallopurpurin derivative SnET2 were free of tumors while 50% of the animals treated with the free-base purpurin ET2 were free of tumor. Metallopurpurins have intense absorptions in the red region of the visible spectrum, a region with good tissue penetration. The metallopurpurins are easily prepared from the corresponding purpurins with a high degree of purity. This study demonstrates the potential of these photosensitizers for photodynamic cancer therapy.
|
Authors | A R Morgan, G M Garbo, R W Keck, S H Selman |
Journal | Cancer research
(Cancer Res)
Vol. 48
Issue 1
Pg. 194-8
(Jan 01 1988)
ISSN: 0008-5472 [Print] United States |
PMID | 3334995
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Animals
- Male
- Metals
- Neoplasm Transplantation
- Photochemotherapy
- Porphyrins
(therapeutic use)
- Rats
- Rats, Inbred F344
- Urinary Bladder Neoplasms
(drug therapy, pathology)
|