Bromodomain-containing protein 4 and its role in cardiovascular diseases.

Abstract

Bromodomain-containing protein 4 (BRD4), a chromatin-binding protein, is involved in the development of various tumors. Recent evidence suggests that BRD4 also plays a significant role in cardiovascular diseases, such as ischemic heart disease, hypertension, and cardiac hypertrophy. This review summarizes the roles of BRD4 as a potential regulator of various pathophysiological processes in cardiovascular diseases, implicating that BRD4 may be a new therapeutic target for cardiovascular diseases in the future.

• Authors: Liang Li, Wei Xie, Yu Gui, Xi-Long Zheng
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 236 Issue 7 Pg. 4829-4840 (07 2021) ISSN: 1097-4652 [Electronic] United States
• PMID: 33345363 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• BRD4 protein, human
• Cell Cycle Proteins
• Transcription Factors

Topics

• Cardiomegaly (pathology)
• Cell Cycle Proteins (metabolism)
• Humans
• Hypertension (pathology)
• Myocardial Ischemia (pathology)
• Protein Conformation
• Transcription Factors (metabolism)
• Transcription, Genetic (genetics)
• Transcriptional Activation (genetics)
• Vascular Remodeling (physiology)
• Ventricular Remodeling (physiology)