Conducting Polyetheretherketone Nanocomposites with an Electrophoretically Deposited Bioactive Coating for Bone Tissue Regeneration and Multimodal Therapeutic Applications.

Abstract

The use of polyetheretherketone (PEEK) has grown exponentially in the biomedical field in recent decades because of its outstanding biomechanical properties. However, its lack of bioactivity/osteointegration remains an unresolved issue toward its wide use in orthopedic applications. In this work, graphene nanosheets have been incorporated into PEEK to obtain multifunctional nanocomposites. Because of the formation of an electrical percolation network and the π-π* conjugation between graphene and PEEK, the resulting composites have achieved 12 orders of magnitude enhancement in their electrical conductivity and thereby enabled electrophoretic deposition of a bioactive/antibacterial coating consisting of stearyltrimethylammonium chloride-modified hydroxyapatite. The coated composite implant shows significant boosting of bone marrow mesenchymal stem cell proliferation in vitro. In addition, the strong photothermal conversion effect of the graphene nanofillers has enabled laser-induced heating of our nanocomposite implants, where the temperature of the implant can reach 45 °C in 150 s. The unique multifunctionality of the implant has also been demonstrated for photothermal applications such as enhancing bacterial eradication and tumor cell inhibition, as well as bone tissue regeneration in vivo. The results suggest the strong potential of our multifunctional implant in bone repair applications as well as multimodal therapy of challenging bone diseases such as osteosarcoma and osteomyelitis.

• Authors: Miaomiao He, Ce Zhu, Huan Xu, Dan Sun, Chen Chen, Ganjun Feng, Limin Liu, Yubao Li, Li Zhang
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 12 Issue 51 Pg. 56924-56934 (Dec 23 2020) ISSN: 1944-8252 [Electronic] United States
• PMID: 33317266 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Benzophenones
• Coated Materials, Biocompatible
• Ketones
• Polymers
• Quaternary Ammonium Compounds
• stearyltrimethylammonium
• polyetheretherketone
• Polyethylene Glycols
• Graphite
• Durapatite

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Benzophenones
• Bone Regeneration (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Coated Materials, Biocompatible (chemistry, pharmacology, radiation effects)
• Durapatite (pharmacology)
• Electric Conductivity
• Escherichia coli (drug effects)
• Female
• Graphite (chemistry, radiation effects)
• Humans
• Infrared Rays
• Ketones (chemistry, radiation effects)
• Mesenchymal Stem Cells (drug effects)
• Mice, Inbred BALB C
• Nanocomposites (chemistry, radiation effects)
• Neoplasms (drug therapy)
• Osseointegration (drug effects)
• Photothermal Therapy (methods)
• Polyethylene Glycols (chemistry, radiation effects)
• Polymers
• Quaternary Ammonium Compounds (pharmacology)
• Staphylococcus aureus (drug effects)
• Xenograft Model Antitumor Assays