Characterising the arthroplasty in spondyloarthropathy in a large cohort of eighty-seven patients with alkaptonuria.

Abstract

Arthroplasty in the spondyloarthropathy (SPOND) of alkaptonuria (AKU) in incompletely characterised. The aim was to improve the understanding of arthroplasty in AKU through a study of patients attending the National Alkaptonuria Centre (NAC). Eighty-seven patients attended the NAC between 2007 and 2020. Seven only attended once. Fifty-seven attended more than once and received nitisinone 2 mg daily. Twenty-three attended at least twice without receiving nitisinone. Assessments including questionnaire analysis eliciting details of arthroplasty and other surgical treatments for SPOND, 18 FPETCT and CT densitometry at the neck of hip and lumbar spine, as well as photographs of the eyes and ears were acquired from patients attending the National Alkaptonuria Centre (NAC) at baseline when 2 mg nitisinone was commenced, and yearly thereafter. Photographs were scored to derive ochronosis scores. Blood and urine samples were collected for chemical analyses. The prevalence of arthroplasty was 36.8%, similar in males and females, occurring especially in the knees, hips and shoulders. Multiple arthroplasties were found in 29 patients (33.3%) in this cohort. Incident arthroplasty was 6.5% in the nitisinone group and 7.1% in the no-nitisinone group. Incident arthroplasty was 11.3% in the group with baseline arthroplasty and 3.51% in the group without. A strong association of arthroplasty with SPOND (R = 0.5; P << .0001) and ochronosis (R = 0.54; P < .0001) was seen. Nitisinone had no significant effect on incident arthroplasty. Arthroplasty due to ochronosis and SPOND is common in AKU. Nitisinone decreased ochronosis but had no effect on arthroplasty in this cohort.

• Authors: Lakshminarayan R Ranganath, James A Gallagher, John Davidson, Sobhan Vinjamuri
• Journal: Journal of inherited metabolic disease (J Inherit Metab Dis) Vol. 44 Issue 3 Pg. 656-665 (05 2021) ISSN: 1573-2665 [Electronic] United States
• PMID: 33314212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 SSIEM.

Chemical References

• Cyclohexanones
• Nitrobenzoates
• nitisinone

Topics

• Aged
• Alkaptonuria (complications, drug therapy)
• Arthroplasty (statistics & numerical data)
• Cohort Studies
• Cyclohexanones (administration & dosage)
• Female
• Humans
• Linear Models
• Male
• Middle Aged
• Nitrobenzoates (administration & dosage)
• Ochronosis (complications, drug therapy)
• Positron Emission Tomography Computed Tomography
• Spondylarthropathies (diagnostic imaging, surgery)
• United Kingdom