Reconstituted high density lipoprotein (rHDL), a versatile drug delivery nanoplatform for tumor targeted therapy.

Abstract

rHDL is a synthesized drug delivery nanoplatform exhibiting excellent biocompatibility, which possesses most of the advantages of HDL. rHDL shows almost no toxicity and can be degraded to non-toxic substances in vivo. The severe limitation of the application of various antitumor agents is mainly due to their low bioavailability, high toxicity, poor stability, etc. Favorably, antitumor drug-loaded rHDL nanoparticles (NPs), which are known as an important drug delivery system (DDS), help to change the situation a lot. This DDS shows an outstanding active-targeting ability towards tumor cells and improves the therapeutic effect during antitumor treatment while overcoming the shortcomings mentioned above. In the following text, we will mainly focus on the various applications of rHDL in tumor targeted therapy by describing the properties, preparation, receptor active-targeting ability and antitumor effects of antineoplastic drug-loaded rHDL NPs.

• Authors: Yijun Mei, Lu Tang, Qiaqia Xiao, Ziqi Zhang, Ziyao Zhang, Jing Zang, Jianping Zhou, Ying Wang, Wei Wang, Min Ren
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 9 Issue 3 Pg. 612-633 (01 28 2021) ISSN: 2050-7518 [Electronic] England
• PMID: 33306079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Biocompatible Materials
• Lipoproteins, HDL

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Biocompatible Materials (chemistry)
• Cell Proliferation (drug effects)
• Drug Delivery Systems
• Humans
• Lipoproteins, HDL (chemistry)
• Nanoparticles (chemistry)
• Neoplasms (drug therapy, pathology)