Abstract |
The spectrum of neuroendocrine (NE) tumors in the genitourinary tract ranges from the aggressive large and small cell carcinomas to the often benign paraganglioma and well-differentiated neuroendocrine tumor (WD-NET). At least 15 pure lower urinary tract (LUT) WD-NETs have been described. Owing to the rarity of WD-NET in the LUT and the limited number of reported cases, a better definition of their biologic long-term behavior is warranted. Herein, we aim to describe 10 new cases of WD-NET arising in the LUT and expand on follow-up findings. Ten consultation cases were identified and included 6 men and 4 women who ranged from 45 to 73 years of age. Seven cases arose in the bladder with one located in the bladder neck, 1 arose in the prostatic urethra, 1 arose in the female urethra, and 1 arose in the left ureteral orifice. All lesions were confined to the lamina propria, and tumor architecture was pseudoglandular in all cases. Associated cystitis cystica et glandularis was identified in 5 cases; urothelial papilloma and florid von Brunn's nests were found in 2 additional cases. Immunohistochemical staining for synaptophysin and chromogranin was diffusely positive in 9 cases and focal in 1 case, and the Ki-67 proliferation index was 5% or less in all tumors. Follow-up ranged from 37 to 137 months (mean = 82; median = 77), and there was no evidence of residual disease or recurrence in any of the 10 patients during the follow-up period.
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Authors | Maria Del Carmen Rodriguez Pena, Daniela C Salles, Jonathan I Epstein, Sofia Canete-Portillo, Aline C Tregnago, July Ramirez, Abdelrazak Meliti, George J Netto |
Journal | Human pathology
(Hum Pathol)
Vol. 109
Pg. 53-58
(03 2021)
ISSN: 1532-8392 [Electronic] United States |
PMID | 33301750
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Female
- Humans
- Immunohistochemistry
(methods)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(pathology)
- Neuroendocrine Tumors
(metabolism, pathology)
- Urethra
(metabolism, pathology)
- Urinary Bladder
(pathology)
- Urinary Bladder Neoplasms
(pathology)
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