[Clinical evaluation of combination therapy with Fortimicin and Cefotax in the treatment of complicated urinary tract infections].

Abstract

Clinical efficacy of combination therapy using Fortimicin (ASTM) and Cefotax (CTX) was studied in 63 patients with complicated urinary tract infections. The patients received 200 mg of ASTM i.m. and 1 g of CTX i.v. twice a day. The overall clinical efficacy of the treatment was evaluated by criteria proposed by the Japanese UTI Committee. The overall clinical efficacy rate was 68.3%. The rate was 67.3% in the patients with single bacterial infection and 72.7% in those with mixed infections. Subjective side effects were observed in one of the patients. Drug related aggravation in laboratory tests was observed in 8 items in 8 patients, but these were mild changes. We concluded that combination therapy with ASTM and CTX was useful for the treatment of complicated urinary tract infections.

• Authors: S Sakashita, Y Asano, M Togashi, A Maru, T Koyanagi, T Kasai, T Namiji, K Mitsuhashi, I Amino, T Kaneta
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 33 Issue 10 Pg. 1718-23 (Oct 1987) ISSN: 0018-1994 [Print] Japan
• PMID: 3328504 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• fortimicin A
• Cefotaxime

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Aminoglycosides
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Bacteria (isolation & purification)
• Cefotaxime (administration & dosage, therapeutic use)
• Clinical Trials as Topic
• Drug Therapy, Combination
• Female
• Humans
• Injections, Intramuscular
• Injections, Intravenous
• Male
• Middle Aged
• Urinary Tract Infections (drug therapy, microbiology)