Abstract |
Ten patients (3 cases of abscess of vaginal cuff, 1 case of abscess of vaginal cuff complicated with parametritis, 2 cases of pyosalpinx, 1 case each of abscess of abdominal wall, pelvic cellulitis, pyometra with cervical cancer and paraovarian abscess were treated with cefuzonam (CZON), which was administrated by intravenous drip infusion at a dose of 1,000 mg twice a day for 3 to 10 days (6 g to 19 g total). The clinical effectiveness reached 70.0% including 1 excellent case, 6 good cases and 3 poor cases. Bacteria were detected in all the 10 cases, and with CZON treatment, bacterial eradication were obtained in 3 cases, bacteria decreased in 3 cases, no change in 2 cases and bacterial replacement occurred in 2 cases. No abnormal laboratory findings and side effects were noted. From the above results, CZON seemed to be a highly effective and useful agent for gynecological infections.
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Authors | N Ikeno, K Takahashi, H Yamamoto, M Watanabe, H Kishi, Y Watanabe, H Mouri, H Endo, I Shima, T Morizuka |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 40
Issue 10
Pg. 1741-4
(Oct 1987)
ISSN: 0368-2781 [Print] Japan |
PMID | 3327963
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Cephalosporins
- cefuzonam
- Ceftizoxime
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Topics |
- Adult
- Aged
- Bacteria
(isolation & purification)
- Bacterial Infections
(drug therapy, microbiology)
- Ceftizoxime
(analogs & derivatives)
- Cephalosporins
(administration & dosage, therapeutic use)
- Clinical Trials as Topic
- Drug Evaluation
- Female
- Genital Diseases, Female
(drug therapy, microbiology)
- Humans
- Infusions, Intravenous
- Middle Aged
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