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[Clinical trials on cefuzonam in obstetrics and gynecological infections].

Abstract
Ten patients (3 cases of abscess of vaginal cuff, 1 case of abscess of vaginal cuff complicated with parametritis, 2 cases of pyosalpinx, 1 case each of abscess of abdominal wall, pelvic cellulitis, pyometra with cervical cancer and paraovarian abscess were treated with cefuzonam (CZON), which was administrated by intravenous drip infusion at a dose of 1,000 mg twice a day for 3 to 10 days (6 g to 19 g total). The clinical effectiveness reached 70.0% including 1 excellent case, 6 good cases and 3 poor cases. Bacteria were detected in all the 10 cases, and with CZON treatment, bacterial eradication were obtained in 3 cases, bacteria decreased in 3 cases, no change in 2 cases and bacterial replacement occurred in 2 cases. No abnormal laboratory findings and side effects were noted. From the above results, CZON seemed to be a highly effective and useful agent for gynecological infections.
AuthorsN Ikeno, K Takahashi, H Yamamoto, M Watanabe, H Kishi, Y Watanabe, H Mouri, H Endo, I Shima, T Morizuka
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 40 Issue 10 Pg. 1741-4 (Oct 1987) ISSN: 0368-2781 [Print] Japan
PMID3327963 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Cephalosporins
  • cefuzonam
  • Ceftizoxime
Topics
  • Adult
  • Aged
  • Bacteria (isolation & purification)
  • Bacterial Infections (drug therapy, microbiology)
  • Ceftizoxime (analogs & derivatives)
  • Cephalosporins (administration & dosage, therapeutic use)
  • Clinical Trials as Topic
  • Drug Evaluation
  • Female
  • Genital Diseases, Female (drug therapy, microbiology)
  • Humans
  • Infusions, Intravenous
  • Middle Aged

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