Histological localization of 4-S-cysteinylphenol in melanoma-bearing mice.

Abstract

4-S-cysteinylphenol (4-S-CP), the S-homologue of tyrosine, has been recently synthesized as a selective chemotherapeutic agent against malignant melanoma and has been shown to be a specific substrate for tyrosinase in vitro. In vivo incorporation of 4-S-CP into the B16 and Harding Passey (HP) melanomas and the systemic organs have been evaluated by the autoradiographic method. The distribution of the silver grains indicated that 4-S-CP was selectively incorporated into both the B16 and HP melanomas. 4-S-CP was excreted mainly from the kidneys and there was an accumulation of 4-S-CP in the reticulo-endothelial system. These results seemed to contribute to the utilization of 4-S-CP and other related compounds as chemotherapeutic agents against malignant melanoma.

• Authors: T Nakamura, O Matsubara, T Kasuga, J Suzuki, K Ishikawa, S Ito
• Journal: The Bulletin of Tokyo Medical and Dental University (Bull Tokyo Med Dent Univ) Vol. 34 Issue 4 Pg. 93-8 (Dec 1987) ISSN: 0040-8921 [Print] Japan
• PMID: 3327627 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• 4-S-cysteinylphenol
• Cysteine

Topics

• Animals
• Antineoplastic Agents (analysis, pharmacokinetics)
• Bone Marrow (metabolism)
• Brain (metabolism)
• Cysteine (analogs & derivatives, analysis, pharmacokinetics)
• Epidermis (metabolism)
• Histological Techniques
• Kidney Tubules (metabolism)
• Liver (metabolism)
• Melanoma, Experimental (analysis, metabolism)
• Mice
• Mice, Inbred C57BL
• Spleen (metabolism)