Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes.

Abstract

Cancer phototheranostics in the second near-infrared window (NIR-II, 1000-1700 nm) has recently attracted much attention owing to its high efficacy and good safety compared with that in the first near-infrared window (NIR-I, 650-950 nm). However, the lack of theranostic nanoagents with active-targeting features limits its further application in cancer precision therapies. Herein, we constructed platelet-camouflaged nanoprobes with active-targeting characteristics for NIR-II cancer phototheranostics. The as-prepared biomimetic nanoprobes can not only escape phagocytosis by macrophages but also specifically bind to CD44 on the surface of most cancer cells. We evaluated the active-targeting performance of biomimetic nanoprobes in pancreatic cancer, breast cancer, and glioma mouse models and achieved NIR-II photoacoustic imaging with a high signal-to-background ratio and photothermal treatment with excellent tumor growth inhibition. Our results show the great potential of platelet-camouflaged nanoprobes with NIR-II active-targeting features for cancer precision diagnosis and efficient therapies.

• Authors: Xiaorui Geng, Duyang Gao, Dehong Hu, Quanhong Liu, Chengbo Liu, Zhen Yuan, Xuanjun Zhang, Xin Liu, Zonghai Sheng, Xiaobing Wang, Hairong Zheng
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 12 Issue 50 Pg. 55624-55637 (Dec 16 2020) ISSN: 1944-8252 [Electronic] United States
• PMID: 33269904 (Publication Type: Journal Article)

Chemical References

• Fluorescent Dyes
• Liposomes
• Membrane Proteins

Topics

• Animals
• Blood Platelets (cytology, metabolism)
• Cell Line, Tumor
• Cell Membrane (chemistry, metabolism)
• Cell Survival (drug effects)
• Female
• Fluorescent Dyes (chemistry)
• Humans
• Infrared Rays
• Liposomes (chemistry)
• Macrophages (cytology, immunology, metabolism)
• Membrane Proteins (chemistry)
• Mice
• Mice, Nude
• Nanoparticles (chemistry, therapeutic use, toxicity)
• Neoplasms (diagnostic imaging, therapy)
• Phagocytosis
• Photoacoustic Techniques
• Phototherapy
• Transplantation, Homologous