Candida vertebral osteomyelitis: report of three cases and a review of the literature.

Abstract

We have recently treated three patients with Candida vertebral osteomyelitis. In each patient there was at least one characteristic prodromal condition, including trauma, multiple antibiotics following bowel surgery, and acute nonlymphocytic leukemia. All patients were treated successfully with amphotericin B. Based on our findings and a review of the literature, we would recommend a 1.0-1.2 gm total dosage of amphotericin B. Alternative therapeutic choices such as 5FC and/or ketoconazole, under specific clinical conditions, have been successfully employed. However, cure can best be confirmed by post-treatment biopsy.

• Authors: B C Friedman, G L Simon
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 8 Issue 1 Pg. 31-6 (Sep 1987) ISSN: 0732-8893 [Print] United States
• PMID: 3326706 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Amphotericin B

Topics

• Adult
• Aged
• Amphotericin B (therapeutic use)
• Candidiasis (drug therapy)
• Humans
• Lumbar Vertebrae (microbiology)
• Male
• Osteomyelitis (drug therapy, microbiology)
• Spondylitis (drug therapy, microbiology)
• Thoracic Vertebrae (microbiology)