[Cellular immunity and enzyme activity of xenobiotic metabolism in the lymphocytes of normal minipigs and in alcohol and anabol exposures].

Abstract

Immunological indices and activity of xenobiotic metabolism enzymes in lymphocytes were studied on minipigs under normal conditions, under conditions of chronic alcoholic intoxication and after administration of anabol (an immunomodulator) to normal healthy animals and to animals with alcohol intoxication. Age-related differences with respect to the number of T-lymphocytes and activity of lymphocyte glutathione S-transferase were observed in the normal animals, the other indices such as activity of natural killer cells, K-cells, blast cell transformation with concanavalin A and activity of cytochrome c-reductase being independent of the age. Administration of anabol to healthy animals did not alter their immunoenzymatic status. Chronic alcohol intoxication was accompanied by development of secondary immune deficiency characterized by lower immunological indices and lower activity of xenobiotic metabolism enzymes in lymphocytes. Daily exposure to 0.8 g of anabol for 12 days at this background resulted in normalization of the above indices.

• Authors: A V Karaulov, V I Ogarkov, V V Osipov, V N Frash
• Journal: Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology (Antibiot Med Biotekhnol) Vol. 32 Issue 11 Pg. 862-4 (Nov 1987) ISSN: 0233-7525 [Print] Russia (Federation)
• Vernacular Title: Kletochnyĭ immunitet i aktivnost' fermentov metabolizma ksenobiotikov v limfotsitakh u mini-svineĭ v norme i pri deĭstvii alkogolia i anabola.
• PMID: 3326521 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Ethanol
• Glutathione Transferase

Topics

• Adjuvants, Immunologic (therapeutic use)
• Alcoholism (drug therapy, enzymology, immunology)
• Animals
• Drug Evaluation, Preclinical
• Ethanol (toxicity)
• Glutathione Transferase (blood)
• Immunity, Cellular (drug effects)
• Immunologic Deficiency Syndromes (chemically induced, drug therapy, enzymology, immunology)
• Leukocyte Count (drug effects)
• Swine
• Swine, Miniature (immunology)
• T-Lymphocytes (drug effects, enzymology, immunology)